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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
05/02/2020 |
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Actualizado : |
05/02/2020 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
SIGDEL, A.; ABDOLLAHI-ARPANAHI, R.; AGUILAR, I.; PEÑAGARICANO, F. |
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Afiliación : |
ANIL SIGDEL, Department of Animal Sciences, University of Florida, Gainesville, FL, United States; ROSTAM ABDOLLAHI-ARPANAHI, Department of Animal Sciences, University of Florida, Gainesville, FL, United States; IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FRANCISCO PEÑAGARICANO, Department of Animal Sciences, University of Florida, Gainesville, FL, United States; University of Florida Genetics Institute, University of Florida, Gainesville, FL, United States. |
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Título : |
Whole genome mapping reveals novel genes and pathways involved in milk production under heat stress in US Holstein cows. |
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Fecha de publicación : |
2019 |
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Fuente / Imprenta : |
Frontiers in Genetics, 4 October 2019, Volume 10, Article number 928. OPEN ACCESS. Doi: https://doi.org/10.3389/fgene.2019.00928 |
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ISSN : |
1664-8021 |
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DOI : |
10.3389/fgene.2019.00928 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received: 19 May 2019 / Accepted: 05 September 2019 / Published: 04 October 2019.
Specialty section: This article was submitted to Livestock Genomics, a section of the journal Frontiers in Genetics.
Corresponding author: Francisco Peñagaricano - fpenagaricano@ufl.edu |
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Contenido : |
ABSTACT.
Heat stress represents a major environmental factor that negatively affects the health and performance of dairy cows, causing huge economic losses to the dairy industry. Identifying and selecting animals that are thermotolerant is an attractive alternative for reducing the negative effects of heat stress on dairy cattle performance. As such, the objectives of the present study were to estimate genetic components of milk yield, fat yield, and protein yield considering heat stress and to perform whole-genome scans and a subsequent gene-set analysis for identifying candidate genes and functional gene-sets implicated in milk production under heat stress conditions. Data consisted of about 254k test-day records from 17,522 Holstein cows. Multi-trait repeatability test day models with random regressions on a function of temperature-humidity index (THI) values were used for genetic analyses. The models included herd-test-day and DIM classes as fixed effects, and general and thermotolerance additive genetic and permanent environmental as random effects. Notably, thermotolerance additive genetic variances for all milk traits increased across parities suggesting that cows become more sensitive to heat stress as they age. In addition, our study revealed negative genetic correlations between general and thermotolerance additive effects, ranging between ?0.18 to ?0.68 indicating that high producing cows are more susceptible to heat stress. The association analysis identified at least three different genomic regions on BTA5, BTA14, and BTA15 strongly associated with milk production under heat stress conditions. These regions harbor candidate genes, such as HSF1, MAPK8IP1, and CDKN1B that are directly involved in the cellular response to heat stress. Moreover, the gene-set analysis revealed several functional terms related to heat shock proteins, apoptosis, immune response, and oxidative stress, among others. Overall, the genes and pathways identified in this study provide a better understanding of the genetic architecture underlying dairy cow performance under heat stress conditions. Our findings point out novel opportunities for improving thermotolerance in dairy cattle through marker-assisted breeding.
© Copyright © 2019 Sigdel, Abdollahi-Arpanahi, Aguilar and Peñagaricano. MenosABSTACT.
Heat stress represents a major environmental factor that negatively affects the health and performance of dairy cows, causing huge economic losses to the dairy industry. Identifying and selecting animals that are thermotolerant is an attractive alternative for reducing the negative effects of heat stress on dairy cattle performance. As such, the objectives of the present study were to estimate genetic components of milk yield, fat yield, and protein yield considering heat stress and to perform whole-genome scans and a subsequent gene-set analysis for identifying candidate genes and functional gene-sets implicated in milk production under heat stress conditions. Data consisted of about 254k test-day records from 17,522 Holstein cows. Multi-trait repeatability test day models with random regressions on a function of temperature-humidity index (THI) values were used for genetic analyses. The models included herd-test-day and DIM classes as fixed effects, and general and thermotolerance additive genetic and permanent environmental as random effects. Notably, thermotolerance additive genetic variances for all milk traits increased across parities suggesting that cows become more sensitive to heat stress as they age. In addition, our study revealed negative genetic correlations between general and thermotolerance additive effects, ranging between ?0.18 to ?0.68 indicating that high producing cows are more susceptible to heat stress. The association analysis identified at ... Presentar Todo |
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Palabras claves : |
Gene-set analysis; Genetic parameters; Genomic scan; Heat-shock proteins; Thermotolerance. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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URL : |
https://www.frontiersin.org/articles/10.3389/fgene.2019.00928/pdf
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Marc : |
LEADER 03448naa a2200253 a 4500
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005 2020-02-05
008 2019 bl uuuu u00u1 u #d
022 $a1664-8021
024 7 $a10.3389/fgene.2019.00928$2DOI
100 1 $aSIGDEL, A.
245 $aWhole genome mapping reveals novel genes and pathways involved in milk production under heat stress in US Holstein cows.$h[electronic resource]
260 $c2019
500 $aArticle history: Received: 19 May 2019 / Accepted: 05 September 2019 / Published: 04 October 2019. Specialty section: This article was submitted to Livestock Genomics, a section of the journal Frontiers in Genetics. Corresponding author: Francisco Peñagaricano - fpenagaricano@ufl.edu
520 $aABSTACT. Heat stress represents a major environmental factor that negatively affects the health and performance of dairy cows, causing huge economic losses to the dairy industry. Identifying and selecting animals that are thermotolerant is an attractive alternative for reducing the negative effects of heat stress on dairy cattle performance. As such, the objectives of the present study were to estimate genetic components of milk yield, fat yield, and protein yield considering heat stress and to perform whole-genome scans and a subsequent gene-set analysis for identifying candidate genes and functional gene-sets implicated in milk production under heat stress conditions. Data consisted of about 254k test-day records from 17,522 Holstein cows. Multi-trait repeatability test day models with random regressions on a function of temperature-humidity index (THI) values were used for genetic analyses. The models included herd-test-day and DIM classes as fixed effects, and general and thermotolerance additive genetic and permanent environmental as random effects. Notably, thermotolerance additive genetic variances for all milk traits increased across parities suggesting that cows become more sensitive to heat stress as they age. In addition, our study revealed negative genetic correlations between general and thermotolerance additive effects, ranging between ?0.18 to ?0.68 indicating that high producing cows are more susceptible to heat stress. The association analysis identified at least three different genomic regions on BTA5, BTA14, and BTA15 strongly associated with milk production under heat stress conditions. These regions harbor candidate genes, such as HSF1, MAPK8IP1, and CDKN1B that are directly involved in the cellular response to heat stress. Moreover, the gene-set analysis revealed several functional terms related to heat shock proteins, apoptosis, immune response, and oxidative stress, among others. Overall, the genes and pathways identified in this study provide a better understanding of the genetic architecture underlying dairy cow performance under heat stress conditions. Our findings point out novel opportunities for improving thermotolerance in dairy cattle through marker-assisted breeding. © Copyright © 2019 Sigdel, Abdollahi-Arpanahi, Aguilar and Peñagaricano.
653 $aGene-set analysis
653 $aGenetic parameters
653 $aGenomic scan
653 $aHeat-shock proteins
653 $aThermotolerance
700 1 $aABDOLLAHI-ARPANAHI, R.
700 1 $aAGUILAR, I.
700 1 $aPEÑAGARICANO, F.
773 $tFrontiers in Genetics, 4 October 2019, Volume 10, Article number 928. OPEN ACCESS. Doi: https://doi.org/10.3389/fgene.2019.00928
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Registro original : |
INIA Las Brujas (LB) |
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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha actual : |
21/02/2014 |
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Actualizado : |
10/05/2022 |
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Tipo de producción científica : |
Documentos |
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Autor : |
TERRA, J.A.; SAWCHIK, J.; RUIZ, A.; MELO, D. |
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Afiliación : |
JOSÉ ALFREDO TERRA FERNÁNDEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JORGE SAWCHIK PINTOS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ADRIAN RUIZ, La Hectárea Profesionales Asociados.; DANIEL MELO, La Hectárea Profesionales Asociados. |
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Título : |
Variabilidad especial y delineación de zonas de manejo. |
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Fecha de publicación : |
2008 |
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Fuente / Imprenta : |
In: Jornada técnica: agricultura de precisión. Dolores, Soriano, Uruguay: INIA La Estanzuela; La Hectárea Profesionales Asociados, octubre 2008. |
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Páginas : |
p. 34-44. |
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Serie : |
(INIA Serie Actividades de Difusión ; 553). |
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Idioma : |
Español |
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Palabras claves : |
FACTORES ABIOTICOS; FACTORES BIÓTICOS; PRACATICAS DE MANEJO; VARIABILIDAD ESPACIO-TEMPORAL. |
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Thesagro : |
SUELOS. |
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Asunto categoría : |
-- |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16425/1/UY.INIA.SAD.2008.n.553.p.34-44-Terra.pdf
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Marc : |
LEADER 00772naa a2200229 a 4500
001 1033317
005 2022-05-10
008 2008 bl uuuu u00u1 u #d
100 1 $aTERRA, J.A.
245 $aVariabilidad especial y delineación de zonas de manejo.$h[electronic resource]
260 $c2008
300 $ap. 34-44.
490 $a(INIA Serie Actividades de Difusión ; 553).
650 $aSUELOS
653 $aFACTORES ABIOTICOS
653 $aFACTORES BIÓTICOS
653 $aPRACATICAS DE MANEJO
653 $aVARIABILIDAD ESPACIO-TEMPORAL
700 1 $aSAWCHIK, J.
700 1 $aRUIZ, A.
700 1 $aMELO, D.
773 $tIn: Jornada técnica: agricultura de precisión. Dolores, Soriano, Uruguay: INIA La Estanzuela; La Hectárea Profesionales Asociados, octubre 2008.
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